Lower levels of whole blood serotonin in obsessive-compulsive disorder and in schizophrenia with obsessive-compulsive symptoms
Autor: | Qiang Wang, Lingjiang Li, Ning Ma, Liwen Tan, Zexuan Li |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male Obsessive-Compulsive Disorder Serotonin Psychosis medicine.medical_specialty Adolescent medicine.drug_class Statistics as Topic Atypical antipsychotic Comorbidity Internal medicine mental disorders Hamd medicine Humans Psychiatry Clozapine Biological Psychiatry Psychiatric Status Rating Scales Positive and Negative Syndrome Scale Middle Aged medicine.disease Psychiatry and Mental health Schizophrenia Female Schizophrenic Psychology Psychology Anxiety disorder Antipsychotic Agents medicine.drug |
Zdroj: | Psychiatry Research. 150:61-69 |
ISSN: | 0165-1781 |
Popis: | It has been reported that some schizophrenic patients suffer from obsessive-compulsive symptoms (OCS), and clozapine treatment is quite often associated with an occurrence/increase of OCS in schizophrenic patients. The aim of the study was to explore whether differences would exist in the clinical symptomatology and the whole blood serotonin (5-HT) concentrations in patients with obsessive-compulsive disorder (OCD), schizophrenic patients with and without OCS (S + OCS, S − OCS), and clozapine-treated schizophrenic patients with and without clozapine-induced OCS (CLZ + OCS, CLZ − OCS). We found that S + OCS patients (n = 15) showed significantly lower scores on the Hamilton Anxiety Scale (HAMA), but similar levels of compulsions and obsessions using Yale-Brown Obsessive-Compulsive Scale (YBOCS) as compared to the patients (n = 35) with OCD. S + OCS patients scored significantly lower on the Positive and Negative Syndrome Scale (PANSS) but higher on the Hamilton Depression Scale (HAMD) compared with S − OCS patients (n = 19). However, CLZ + OCS patients (n = 15) suffered from dominant compulsions but fewer obsessions compared with the OCD and S + OCS patients. OCD, S + OCS and CLZ + OCS groups had significantly lower levels of whole blood 5-HT than did the healthy volunteers (n = 15), S − OCS and CLZ − OCS groups. It suggests that alterations in serotonin metabolism may be a common biological characteristic of OCS in OCD as well as in schizophrenia. |
Databáze: | OpenAIRE |
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