Action perception recruits the cerebellum and is impaired in patients with spinocerebellar ataxia
| Autor: | Ritu Bhandari, Christian Keysers, Robin Broersen, Chris I. De Zeeuw, Samuel Picard, Valeria Gazzola, Abdel R. Abdelgabar, Judith Suttrup |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Neurosciences, FMG, Brein en Cognitie (Psychologie, FMG) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities Cerebellum Movement disorders Motion Perception social cognition PRIMARY SOMATOSENSORY CORTEX cerebellar function Social cognition AREAS IMITATION medicine Humans Spinocerebellar Ataxias Spinocerebellar ataxia type 6 Cerebellar disorder BRAIN MOTOR CORTEX MIRROR NEURON SYSTEM Brain Mapping LESIONS medicine.diagnostic_test Original Articles HAND ACTIONS medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure imaging methodology nervous system FMRI spincocerebellar ataxia Spinocerebellar ataxia movement disorders Female Neurology (clinical) medicine.symptom Psychology Functional magnetic resonance imaging Neuroscience Psychomotor Performance INFERIOR PARIETAL Motor cortex |
| Zdroj: | Brain, 142, 3791-3805. Oxford University Press Brain, 142(12), 3791-3805. Oxford University Press Brain |
| ISSN: | 0006-8950 |
| Popis: | Using a combination of neuroimaging and behavioural studies, Abdelgabar et al. show that the cerebellum helps us perceive the actions of others. Disorders such as spinocerebellar ataxia type 6, which disrupt cerebellar functioning, impair our ability to perceive the kinematics of other people’s actions, with potential implications for social cognition. Our cerebellum has been proposed to generate prediction signals that may help us plan and execute our motor programmes. However, to what extent our cerebellum is also actively involved in perceiving the action of others remains to be elucidated. Using functional MRI, we show here that observing goal-directed hand actions of others bilaterally recruits lobules VI, VIIb and VIIIa in the cerebellar hemispheres. Moreover, whereas healthy subjects (n = 31) were found to be able to discriminate subtle differences in the kinematics of observed limb movements of others, patients suffering from spinocerebellar ataxia type 6 (SCA6; n = 21) were severely impaired in performing such tasks. Our data suggest that the human cerebellum is actively involved in perceiving the kinematics of the hand actions of others and that SCA6 patients’ deficits include a difficulty in perceiving the actions of other individuals. This finding alerts us to the fact that cerebellar disorders can alter social cognition. |
| Databáze: | OpenAIRE |
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