Effects of retinoic acid on compensatory lung growth
| Autor: | Ünal Açikel, Aydin Sanli, Oya Sivrikoz, Ahmet Önen, Sami Karapolat |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology medicine.medical_treatment Keratolytic Treatment outcome lcsh:Surgery Retinoic acid Tretinoin lcsh:RD78.3-87.3 chemistry.chemical_compound Pneumonectomy Keratolytic Agents Internal medicine Animals Regeneration Medicine Rats Wistar Lung business.industry Regeneration (biology) Contralateral lung Organ Size lcsh:RD1-811 General Medicine respiratory system Rats respiratory tract diseases Pulmonary Alveoli Disease Models Animal Treatment Outcome medicine.anatomical_structure Endocrinology chemistry lcsh:Anesthesiology Surgery Cardiology and Cardiovascular Medicine business Research Article medicine.drug |
| Zdroj: | Journal of Cardiothoracic Surgery, Vol 3, Iss 1, p 37 (2008) Journal of Cardiothoracic Surgery |
| ISSN: | 1749-8090 |
| DOI: | 10.1186/1749-8090-3-37 |
| Popis: | Background We investigated the effect of Retinoic acid in the growth of contralateral lung after pneumonectomy. Methods Twentyone adult male Wistar albino rats from the same colony were used. They were divided into three groups (Group A, B and C). Group A undergone only left posterolateral thoracotomy. In Group B and C, the rats were subjected to left posterolateral thoracotomy and left pneumonectomy. In Group C, rats were given intraperitoneal Retinoic acid during the operation and continued to be given everyday postoperatively. Rats were sacrificed on the 10th day and their total body, right lung weights and right lung volumes were measured. Results The volume and weight indices of the lung were found to be higher in Group C. In histopathological examination, there was a reduction in the mean number of alveoli in Group B and C. A significant rise in the mean dimension and average wall thickness of the alveolar structure were determined in Group C. Conclusion Retinoic acid contributes to the compensatory growth of the residual lung tissue. |
| Databáze: | OpenAIRE |
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