Distinct evolutionary trajectories of V1R clades across mouse species
Autor: | Caitlin H. Miller, Michael J. Sheehan, Polly Campbell |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0106 biological sciences
0301 basic medicine Clade Vomeronasal organ Range (biology) Evolution Pheromone Gene expansion Olfaction V1R Biology 010603 evolutionary biology 01 natural sciences House mouse Evolution Molecular Mice 03 medical and health sciences 0302 clinical medicine Species Specificity QH359-425 Animals Gene family Selection Genetic Receptor Gene Phylogeny Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Mus biology.organism_classification Receptors Pheromone 030104 developmental biology Evolutionary biology Sex pheromone Female Vomeronasal Organ Transcriptome Vomeronasal 030217 neurology & neurosurgery Research Article Social behavior |
Zdroj: | BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-16 (2020) BMC Evolutionary Biology |
ISSN: | 1471-2148 |
Popis: | Background Many animals rely heavily on olfaction to navigate their environment. Among rodents, olfaction is crucial for a wide range of social behaviors. The vomeronasal olfactory system in particular plays an important role in mediating social communication, including the detection of pheromones and recognition signals. In this study we examine patterns of vomeronasal type-1 receptor (V1R) evolution in the house mouse and related species within the genus Mus. We report the extent of gene repertoire turnover and conservation among species and clades, as well as the prevalence of positive selection on gene sequences across the V1R tree. By exploring the evolution of these receptors, we provide insight into the functional roles of receptor subtypes as well as the dynamics of gene family evolution. Results We generated transcriptomes from the vomeronasal organs of 5 Mus species, and produced high quality V1R repertoires for each species. We find that V1R clades in the house mouse and relatives exhibit distinct evolutionary trajectories. We identify putative species-specific gene expansions, including a large clade D expansion in the house mouse. While gene gains are abundant, we detect very few gene losses. We describe a novel V1R clade and highlight candidate receptors for future study. We find evidence for distinct evolutionary processes across different clades, from largescale turnover to highly conserved repertoires. Patterns of positive selection are similarly variable, as some clades exhibit abundant positive selection while others display high gene sequence conservation. Based on clade-level evolutionary patterns, we identify receptor families that are strong candidates for detecting social signals and predator cues. Our results reveal clades with receptors detecting female reproductive status are among the most conserved across species, suggesting an important role in V1R chemosensation. Conclusion Analysis of clade-level evolution is critical for understanding species’ chemosensory adaptations. This study provides clear evidence that V1R clades are characterized by distinct evolutionary trajectories. As receptor evolution is shaped by ligand identity, these results provide a framework for examining the functional roles of receptors. |
Databáze: | OpenAIRE |
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