Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery
| Autor: | Sofia Bougioukli, Steven C. Ghivizzani, Jay R. Lieberman, Ram K. Alluri, Christopher H. Evans |
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| Rok vydání: | 2018 |
| Předmět: |
Cartilage
Articular 0301 basic medicine medicine.medical_specialty Genetic enhancement Disease Osteoarthritis 03 medical and health sciences Drug Discovery Genetics medicine Articular cartilage repair Animals Humans Intensive care medicine Molecular Biology Genetics (clinical) Fracture Healing Bone Development Tissue Engineering business.industry Genetic Therapy medicine.disease Clinical trial Intervertebral disk Orthopedics 030104 developmental biology Orthopedic surgery Musculoskeletal injury Molecular Medicine Bone Diseases business Cartilage Diseases |
| Zdroj: | Current Gene Therapy. 18:154-170 |
| ISSN: | 1566-5232 |
| DOI: | 10.2174/1566523218666180410152842 |
| Popis: | Musculoskeletal conditions are a major public health problem. Approximately 66 million individuals seek medical attention for a musculoskeletal injury in the United States, with current medical costs being estimated at $873 billion annually. Despite advances in pharmaceuticals, implant materials and surgical techniques, there remains an unmet clinical need for successful treatment of challenging musculoskeletal injuries and pathologic conditions, particularly in the setting of compromised biological environments. Tissue engineering via gene therapy attempts to provide an alternative treatment strategy to address the deficits associated with conventional approaches. The transfer of specific target genes coding for proteins with therapeutic or regenerative properties to target cells and tissues in the disease environment allows for their sustained production and release specifically at the site of interest. The increasing reports of success with gene therapy-based treatments in the clinical management of a variety of diseases provide genuine optimism that similar methods can be adapted for mainstream clinical application in musculoskeletal disorders. In preclinical studies, gene therapy has been successfully used to treat cartilaginous, bone, skeletal muscle, tendon, ligament and intervertebral disk injuries. In addition, gene therapy is being assessed in clinical trials for its safety and therapeutic potential in osteoarthritis. This review will specifically address the clinical potential, preclinical data and future hurdles for gene therapy to be a viable clinical entity for the treatment of fracture nonunion and difficult bone repair scenarios, articular cartilage repair and osteoarthritis. |
| Databáze: | OpenAIRE |
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