Anticholinesterase insecticide action at the murine male reproductive system
| Autor: | Himiko Suzuki, Yuki Noro, Michihiro Kamijima, Yuki Ito, Keisuke Abe, Motohiro Tomizawa |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Insecticides Clinical Biochemistry Pharmaceutical Science Motility Pharmacology Biology Biochemistry Amidohydrolases Mice Fatty acid amide hydrolase Drug Discovery medicine Animals Male reproductive system Molecular Biology Molecular Structure Organic Chemistry Epididymis Spermatozoa Enzyme Activation Monoacylglycerol lipase medicine.anatomical_structure Molecular Medicine Cholinesterase Inhibitors Genital Diseases Male |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 23:5434-5436 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2013.07.021 |
| Popis: | The present report describes for the first time that anticholinesterase type insecticides specifically inhibit the fatty acid amide hydrolase and/or monoacylglycerol lipase, as secondary target(s), in the murine male reproductive system (testis and epididymis cauda), thereby presumably being involved with spermatotoxicity such as deformity, underdevelopment, and reduced motility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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