Cerebrovascular reactivity after cessation of menopausal hormone treatment
| Autor: | Ronée E. Harvey, Virginia M. Miller, Michael J. Joyner, Sarah Kruse, Brian D. Lahr, Jill N. Barnes, Kathleen B. Miller, Maja Johnson, Nicole A. Eisenmann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.drug_class
Physiology Blood Pressure Article Placebos Cerebrovascular reactivity medicine Humans Estrogens Conjugated (USP) Postmenopausal women Estradiol business.industry Estrogen Replacement Therapy Brain Obstetrics and Gynecology Estrogens General Medicine Carbon Dioxide Cerebral Arteries Middle Aged medicine.disease Menopause Cerebrovascular Disorders Blood pressure Cerebral hemodynamics Estrogen Cerebrovascular Circulation Pulsatile Flow Female Menopausal hormone therapy business Blood Flow Velocity Hormone |
| Zdroj: | Climacteric. 22:182-189 |
| ISSN: | 1473-0804 1369-7137 |
| DOI: | 10.1080/13697137.2018.1538340 |
| Popis: | OBJECTIVE: Women who are currently using menopausal hormone therapy (MHT) have higher cerebrovascular reactivity when compared with postmenopausal women who are not taking MHT; however the effect of cessation of MHT on cerebrovascular reactivity is not known. Given that MHT can have structural and activational effects on vascular function, this study was performed to characterize cerebrovascular reactivity following cessation of MHT in women at low risk for cerebrovascular disease. METHODS: Cerebrovascular reactivity measured in a subset of women from the Kronos Early Estrogen Prevention Study (KEEPS) three years after the cessation of the study drug [oral conjugated equine estrogen (oCEE); transdermal 17-β estradiol (tE2); or placebo (PLA)]. RESULTS: Age, body mass index, and blood pressure were comparable among groups. At rest, middle cerebral artery velocity (MCAv), cerebrovascular conductance index (CVCi), mean arterial pressure (MAP) and cerebral pulsatility index did not differ among groups. Slope-based summary measures of cerebrovascular reactivity did not differ significantly among groups. However, utilizing repeated measures modeling, there was a significant upward shift in MCAv responses (p=0.029) in the combined MHT group compared with PLA group. CONCLUSION: MHT has a marginal sustained effect on cerebrovascular reactivity when measured three years after cessation of hormone treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|