Meningococcal interactions with the host
| Autor: | Mumtaz Virji, Sandrine Bourdoulous, Darryl J. Hill, Etienne Carbonnelle, Natalie J. Griffiths, Xavier Nassif, Isabel Murillo, Philippe Morand |
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| Rok vydání: | 2009 |
| Předmět: |
Virulence Factors
Neisseria meningitidis medicine.disease_cause Bacterial Adhesion Pilus Microbiology Immune system Antigen medicine Humans Adhesins Bacterial Phase variation General Veterinary General Immunology and Microbiology biology Host (biology) Public Health Environmental and Occupational Health Endothelial Cells Epithelial Cells biology.organism_classification Bacterial adhesin Infectious Diseases Host-Pathogen Interactions Molecular Medicine Neisseriaceae |
| Zdroj: | Vaccine. 27:B78-B89 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2009.04.069 |
| Popis: | Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins; many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. |
| Databáze: | OpenAIRE |
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