Effect of arterial hypertension on chronic urticaria duration
| Autor: | Nicoletta Ferrero, Gloria Castiglioni, Enrico Heffler, Aurelia Carosso, F. Nebiolo, Giuseppe Guida, Roberta Bergia, Sabrina Mietta, Massimiliano Bugiani, Stefano Pizzimenti, Iuliana Badiu, Giovanni Rolla, Luisa Bommarito |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Allergy Adolescent Urticaria Immunology Histamine Antagonists Cohort Studies Atopy Internal medicine medicine Humans Immunology and Allergy Prospective cohort study Aged Proportional Hazards Models Aged 80 and over Angioedema business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Confidence interval Surgery Treatment Outcome Chronic Disease Hypertension Cohort Disease Progression Female medicine.symptom business Follow-Up Studies |
| Popis: | Background Reliable clinical or laboratory markers of chronic idiopathic urticaria (CIU) duration are not available. Angioedema, autologous serum skin test (ASST) results, and antithyroid antibodies have been inconsistently associated with longer urticaria duration. Objective To investigate the association of clinical and laboratory parameters with CIU duration, including systemic hypertension, because activation of the coagulation cascade pathway may contribute to the pathogenesis of CIU. Methods We performed a prospective study of a cohort of 228 consecutive adult patients with CIU of moderate to severe intensity referred to 2 outpatient allergy clinics and followed up for a 3- to 5-year period. The association of clinical and laboratory parameters (sex, atopy, markers of autoimmunity, antithyroid antibodies, positive ASST result, Helicobacter pylori infection, and hypertension) with urticaria duration was analyzed using semiparametric multivariable proportional hazards models (Cox regression) using remission as main outcome measure. Results Apart from systemic hypertension (hazard ratio, 0.71; 95% confidence interval, 0.53-0.95; P =.02), none of the considered parameters influenced CIU remission of our patients; 74% and 54% of our patients with and without hypertension, respectively, still had CIU after 5 years. Conclusions Our results show, for the first time to our knowledge, that hypertension is associated with extended duration of CIU. This observation, together with the previous findings that point to vascular and coagulation involvement in CIU, may suggest a new approach to antihistamine-refractory CIU treatment, including adequate treatment of hypertension. |
| Databáze: | OpenAIRE |
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