Liver stiffness regression after successful Hepatitis C treatment is independent of HIV coinfection
| Autor: | Ulrich Spengler, Jonel Trebicka, S Schlabe, Bonaventura Clotet, Josep M. Llibre, Juergen K. Rockstroh, Christoph Boesecke, JC Wasmuth, Jakob J Malin, Carolynne Schwarze-Zander, M Vasylyev, T Jou |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Multivariate analysis Sustained Virologic Response Hepatitis C virus HIV Infections medicine.disease_cause Gastroenterology Antiviral Agents 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine Medicine Humans Pharmacology (medical) 030212 general & internal medicine business.industry Health Policy Odds ratio Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease 030112 virology Regression Infectious Diseases Treatment Outcome Liver Coinfection Elasticity Imaging Techniques Female business Transient elastography |
| Zdroj: | HIV medicine. 20(3) |
| ISSN: | 1468-1293 |
| Popis: | OBJECTIVES The aim of the study was to assess the regression of liver stiffness after successful direct-acting antiviral (DAA) treatment in patients with hepatitis C virus (HCV) monoinfection and HCV/-HIV coinfection. In addition, we aimed to identify factors associated with liver stiffness regression. METHODS We studied patients treated with interferon-free DAA regimens with a sustained virological response at week 12 (SVR12 ) or 24 (SVR24 ) post-treatment. Liver stiffness was assessed by transient elastography (TE) before the initiation and after the end of treatment (median 12 weeks). RESULTS Of 214 enrolled patients, 85 (40%) were HCV monoinfected and 129 (60%) HCV/HIV coinfected. Baseline median TE values were 7.8 kPa [interquartile range (IQR) 5.9-12.0 kPa] in mono-infected patients and 10.7 kPa (IQR 7.8-17.0 kPa) in coinfected patients. Overall, the median TE value decreased from 10.1 to 6.8 kPa (n = 214; P |
| Databáze: | OpenAIRE |
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