Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
| Autor: | Thomas Tommy, Agussalim Bukhari, Mochammad Hatta, Andi Asadul Islam |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
HMGB1
Inflammation biology business.industry Damage-associated molecular pattern chemical and pharmacologic phenomena General Medicine Review Bioinformatics RAGE (receptor) Review article Inflammation Process 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis biology.protein Medicine 030211 gastroenterology & hepatology Surgery medicine.symptom Brain injury business Neuroinflammation |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Background Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced glycation end products (RAGE), will cause positive amplification of inflammation signalling pathway. Brain injury is one of the major contributors for disability and death which neuroinflammation has a major role in its pathogenesis and influencing its outcome. In neuroinflammation, it has been described that HMGB1 may have a pivotal role in the process. Objective The objective of this article is to review the role HMGB1 in brain injury and its immunomodulatory properties. Methods A comprehensive search of literature was conducted in PubMed (NIH), Scopus, EMBASE, and Google Scholar database using keyword combinations of the medical subject headings (MeSH) of “HMGB1” and “Brain Injury” and relevant reference lists were also manually searched. All relevant articles of any study design published from year 1990 till June 2020, were included and narratively discussed in this review. Results Twenty-four articles were shortlisted and reviewed in this article. Through these articles, we synthesis information on the function and metabolism of HMGB1, immunomodulatory effect of HMGB1, clinical findings and other potential treatment involving HMGB1, and role of HMGB1 protein in brain injury. Conclusion HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways.Review registration number reviewregistry966 in www.researchregistry.com. Highlights • HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways. • This pro-inflammatory process needs to be balanced with anti-inflammatory agents for homeostasis. • Further studies are needed to support anti HMGB1 therapy in inflammation process. |
| Databáze: | OpenAIRE |
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