Effect of modified live or inactivated feline herpesvirus-1 parenteral vaccines on clinical and laboratory findings following viral challenge
| Autor: | Michael R. Lappin, Rebecca Ruch-Gallie, Jennifer R. Hawley, Stacie C Summers |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male 040301 veterinary sciences Injections Subcutaneous Cat Diseases Vaccines Attenuated Virus law.invention 0403 veterinary science 03 medical and health sciences Randomized controlled trial law Medicine Animals Viral shedding Small Animals Herpesviridae Feline calicivirus CATS biology business.industry Inoculation Respiratory disease Vaccination Viral Vaccines 04 agricultural and veterinary sciences Herpesviridae Infections medicine.disease biology.organism_classification Specific Pathogen-Free Organisms Virus Shedding 030104 developmental biology Treatment Outcome Animals Newborn Vaccines Inactivated Immunology Cats Female business Calicivirus Feline |
| Zdroj: | Journal of feline medicine and surgery. 19(8) |
| ISSN: | 1532-2750 |
| Popis: | Objectives The objective was to investigate the effect of one dose of an inactivated feline herpesvirus-1 (FHV-1), feline calicivirus (FCV) and panleukopenia virus (FPV) vaccine (FVRCP) or one dose of a modified live (ML) FVRCP vaccine on clinical signs and shedding of FHV-1 in specific pathogen-free kittens after challenge with FHV-1 7 days after vaccination. Methods Twenty-four FHV-1 seronegative 5-month-old kittens were randomized into three groups of eight kittens. Group 1 kittens were maintained as unvaccinated controls, group 2 kittens were administered one dose of the inactivated FVRCP vaccine subcutaneously (SC) and group 3 kittens were administered one dose of the ML FVRCP vaccine SC. All 24 cats were administered FHV-1 by nasal and oropharyngeal inoculation 7 days later and were observed daily for clinical signs of illness for 21 days. Results In the 21 days after FHV-1 challenge, both groups of vaccinated cats were less likely to be clinically ill (indicated by lower cumulative clinical scores) than control cats ( P Conclusions and relevance Parenteral administration of either the inactivated FVRCP vaccine or the ML FVRCP vaccine can decrease clinical signs of illness due to FHV-1 on a day 7 challenge when compared with controls. Use of either vaccine product is indicated in cats at risk of acute exposure to FHV-1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|