FRONTotemporal dementia Incidence European Research Study—FRONTIERS
| Autor: | Giancarlo Logroscino, Marco Piccininni, Barbara Borroni, James B. Rowe, Anne M. Remes, Orla Hardiman, Latchezar Traykov, Harro Seelaar, Albert C. Ludolph, Markus Otto, Elka Stefanova, Caroline Graff, Frontiers, Fermin Moreno |
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| Přispěvatelé: | Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Gerontology
medicine.medical_specialty Referral epidemiology [Frontotemporal Dementia] registry frontotemporal dementia Cohort Studies 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience SDG 3 - Good Health and Well-being Epidemiology mental disorders medicine Humans ddc:610 Prospective Studies genetics [Frontotemporal Dementia] Disease burden epidemiology [Frontotemporal Lobar Degeneration] 030304 developmental biology 0303 health sciences business.industry Health Policy Incidence (epidemiology) Incidence nutritional and metabolic diseases rare diseases Frontotemporal lobar degeneration medicine.disease 3. Good health nervous system diseases Psychiatry and Mental health frontotemporal lobar degeneration Frontotemporal Dementia Population study Observational study epidemiology Neurology (clinical) genetics [Frontotemporal Lobar Degeneration] Geriatrics and Gerontology business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Alzheimer's and dementia 18(3), 498-506 (2022). doi:10.1002/alz.12414 |
| ISSN: | 1552-5260 |
| Popis: | Introduction The incidence of Frontotemporal Lobar Degeneration (FTLD)-related disorders and their characteristics are not well known. The "FRONTotemporal dementia Incidence European Research Study" (FRONTIERS) is designed to fill this gap. Methods FRONTIERS is a European prospective, observational population study based on multinational registries. FRONTIERS comprises 11 tertiary referral centers across Europe with long-lasting experience in FTLD-related disorders and comprehensive regional referral networks, enabling incidence estimation over well-defined geographical areas. Endpoints The primary endpoints are (1) the incidence of FTLD-related disorders across Europe; (2) geographic trends of FTLD-related disorders; (3) the distribution of FTLD phenotypes in different populations and ethnicities in Europe; (4) inheritance of FTLD-related disorders, including the frequencies of monogenic FTLD as compared to overall disease burden; and (5) implementation of data banking for clinical and biological material. Expected impacts FRONTIERS will improve the understanding of FTLD-related disorders and their epidemiology, promoting appropriate public health service policies and treatment strategies. |
| Databáze: | OpenAIRE |
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