In Vivo Partial Restoration of Neural Activity across Severed Mouse Spinal Cord Bridged with Ultralong Carbon Nanotubes
| Autor: | Swastik Kar, Vineet Mathur, Saikat Talapatra, Zachariah Hennighausen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Neurons
Artifact rejection Materials science Nanotubes Carbon Biochemistry (medical) Biomedical Engineering Biocompatible Materials General Chemistry Carbon nanotube medicine.disease Low impedance law.invention Biomaterials Mice Neural activity Mouse Spinal Cord Spinal Cord In vivo law Materials Testing medicine Biophysics Animals Particle Size Spinal cord injury |
| Zdroj: | ACS Applied Bio Materials. 4:4071-4078 |
| ISSN: | 2576-6422 |
| Popis: | Electrically bridging severed nerves in vivo has transformative healthcare implications, but current materials are inadequate. Carbon nanotubes (CNTs) are promising, with low impedance, high charge injection capacity, high flexibility, are chemically inert, and can electrically couple to neurons. Ultralong CNTs are unexplored for neural applications. Using only ultralong CNTs in saline, without neuroregeneration or rehabilitation, we partially restored neural activity across a severed mouse spinal cord, recovering 23.8% of the intact amplitude, while preserving signal shape. Neural signals are preferentially facilitated over artifact signals by a factor of ×5.2, suggesting ultralong CNTs are a promising material for neural-scaffolding and neural-electronics applications. |
| Databáze: | OpenAIRE |
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