Predictors of radiographic progression in the ESPOIR cohort: the season of first symptoms may influence the short-term outcome in early arthritis
| Autor: | Mouterde, G., Lukas, C., Logeart, I., Flipo, R. M., Rincheval, N., Daurès, J. P., Combe, B., Saraux, Alain |
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| Přispěvatelé: | Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Service de rhumatologie[Lille], Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2011 |
| Předmět: |
Male
MESH: Synovitis [SDV]Life Sciences [q-bio] MESH: Epidemiologic Methods Logistic regression Arthritis Rheumatoid 0302 clinical medicine MESH: Early Diagnosis MESH: Autoantibodies Immunology and Allergy MESH: HLA-DRB1 Chains MESH: Aged MESH: Arthritis Rheumatoid 0303 health sciences Univariate analysis Synovitis MESH: Middle Aged medicine.diagnostic_test Middle Aged Prognosis 3. Good health MESH: Young Adult Rheumatoid arthritis Erythrocyte sedimentation rate Cohort Disease Progression Female MESH: Disease Progression Seasons Adult medicine.medical_specialty MESH: Rheumatoid Factor Immunology MESH: Arthritis Blood Sedimentation Peptides Cyclic MESH: Prognosis General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences Rheumatology Rheumatoid Factor Internal medicine medicine Humans Rheumatoid factor MESH: Blood Sedimentation MESH: Peptides Cyclic Aged Autoantibodies 030304 developmental biology 030203 arthritis & rheumatology MESH: Humans Receiver operating characteristic business.industry Arthritis MESH: Biological Markers MESH: Adult HLA-DR Antigens MESH: HLA-DR Antigens medicine.disease MESH: Male Surgery Radiography Early Diagnosis Epidemiologic Methods business MESH: Female MESH: Seasons Biomarkers HLA-DRB1 Chains |
| Zdroj: | Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, BMJ Publishing Group, 2011, 70 (7), pp.1251-6. ⟨10.1136/ard.2010.144402⟩ |
| ISSN: | 0003-4967 1468-2060 |
| Popis: | International audience; OBJECTIVES: To determine predictors of short-term radiographic progression in an inception cohort of patients with early arthritis. METHODS: Patients presenting with synovitis of at least two joints for 6 weeks to 6 months were included in the Etude et Suivi des POlyarthrites Indifferenciées Récentes (ESPOIR) cohort. Univariate analysis was used to determine the relationship between baseline variables and radiographic outcome (assessed by the modified total Sharp score (mTSS)) after 6 and 12 months. Stepwise multiple logistic regression was used to select independent predictive factors. The sensitivity and specificity of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) at baseline in discriminating between erosive and non-erosive disease were determined by receiver operating characteristic (ROC) curves. RESULTS: From data available for 736 patients, radiographic progression at 6 months was independently predicted by baseline ACPA, human leucocyte antigen (HLA)-DRB1*01 and/or 04 genes, erythrocyte sedimentation rate and mTSS. Interestingly, the season of onset of the first symptoms was associated with the severity of early arthritis (OR 1.66, 95% CI 1.07 to 2.59, in winter and spring vs summer and autumn). Univariate analysis revealed similar results for season at 12 months (OR 1.68, 95% CI 1.20 to 2.37). The peak of the ROC curves for radiographic outcome occurred with ACPA and RF values similar to the cut-offs provided by manufacturers. CONCLUSION: The authors found the onset of arthritis symptoms during winter or spring associated with greater radiographic progression at 6 months for patients with early arthritis. These data could reinforce the role of environmental factors in the development and outcome of rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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