Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides
| Autor: | Ilias Mylonis, Evangelos Kouvaras, Maria Ioannou, A V Roussaki-Schulze, Rodula Papamichali, Paraskevi Siomou, Efterpi Zafiriou, E Klimi, Fani Sourli, George Simos, George K. Koukoulis, Sotirios Barbanis |
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| Rok vydání: | 2009 |
| Předmět: |
Keratinocytes
Pathology medicine.medical_specialty Histology medicine.diagnostic_test business.industry Alpha (ethology) Inflammation Dermatitis Dermatology medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Immunohistochemistry Pathology and Forensic Medicine HIF1A Hypoxia-inducible factors Psoriasis Biopsy medicine Humans medicine.symptom business Immunostaining |
| Zdroj: | Journal of cutaneous pathology. 36(12) |
| ISSN: | 1600-0560 |
| Popis: | Background: Expression of hypoxia inducible factor 1 (HIF-1) alpha can be linked to inflammation through reciprocal interactions with several cytokines. This finding is in accordance with the previously noted HIF-1 alpha overexpression in psoriatic lesional keratinocytes. Methods: In this study we have employed a carefully selected panel of antibodies and quantitative morphometric analysis to compare HIF-1 alpha immunoreactivity in psoriatic biopsy samples vs. that in samples obtained from psoriasiform dermatitides. Results: We found statistically significant HIF-1 alpha overexpression in psoriasis. Furthermore, we observed a previously unreported preferential localization of immunoreactive keratinocytes in the immediate vicinity of inflamed and elongated papillae. This pattern of immunoreactivity may partially account for the observed increase of HIF-1 alpha immunostaining in psoriasis. Conclusions: Overall, our findings imply that possible novel therapeutic intervention(s) on the HIF-1 alpha pathway may offer another approach in controlling the inflammatory activity of psoriatic lesions. |
| Databáze: | OpenAIRE |
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