A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination
| Autor: | Wendy Qiu, Logan R. J. Bailey, Ajay N. Sharma, Hung D. Tran, Connor J. Beebout, Shubhang K. Bhatt, Anusha Deshpande, Roberto J. Pezza, Huanyu Qiao, H.B.D. Prasada Rao, Neil Hunter, Sarah L. Bourne |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Proteasome Endopeptidase Complex General Science & Technology Ubiquitin-Protein Ligases 1.1 Normal biological development and functioning Cell Cycle Proteins Article Chromosomes Ligases 03 medical and health sciences Mice 0302 clinical medicine Prophase Ubiquitin Meiosis Genetic Spermatocytes Underpinning research Crossing Over Genetics Animals Recombination Genetic Multidisciplinary biology Mammalian Synapsis Ubiquitination Cell biology Mutant Strains Chromosome Pairing 030104 developmental biology Proteasome Proteolysis biology.protein Small Ubiquitin-Related Modifier Proteins Generic health relevance Protein stabilization Homologous recombination 030217 neurology & neurosurgery Recombination Biotechnology |
| Zdroj: | Science (New York, N.Y.), vol 355, iss 6323 |
| Popis: | Proteasomes and SUMO wrestle chromosomes Meiosis is the double cell division that generates haploid gametes from diploid parental cells. Pairing of homologous chromosomes during the first meiotic division ensures that each gamete receives a complete set of chromosomes. The proteasome, on the other hand, is a molecular machine that degrades proteins tagged for destruction within the cell (see the Perspective by Zetka). Ahuja et al. show that the proteasome is also involved in ensuring that homologous chromosomes pair with each other during meiosis. Rao et al. show that the SUMO (small ubiquitin-like modifier) protein, ubiquitin, and the proteasome localize to the axes between homologous chromosomes. In this location, they help mediate chromosome pairing and recombination between homologs. Science , this issue p. 349 , p. 408 ; see also p. 403 |
| Databáze: | OpenAIRE |
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