Average 2.5‐year neurodevelopmental test results in children born very preterm did not rule out cognitive deficits at 6.5 years of age

Autor: Katarina Strand Brodd, Nima Naseh, Birgitta Böhm, Ylva Fredriksson Kaul, Gerd Holmström, Lena Hellström-Westas
Rok vydání: 2020
Předmět:
Pediatrics
medicine.medical_specialty
Gestational Age
Bayley Scales of Infant Development
03 medical and health sciences
Child Development
Cognition
0302 clinical medicine
visuomotor integration
030225 pediatrics
follow-up
Humans
retinopathy of prematurity
Medicine
Cognitive Dysfunction
Prospective Studies
030212 general & internal medicine
Toddler
Prospective cohort study
follow‐up
neurodevelopment
Intelligence quotient
business.industry
Infant
Newborn
Pediatrik
Infant
Gestational age
Wechsler Adult Intelligence Scale
Regular Article
Retinopathy of prematurity
General Medicine
medicine.disease
Infant
Extremely Premature
Relative risk
Pediatrics
Perinatology and Child Health
Regular Articles & Brief Reports
Outcome after Preterm Birth
Wechsler Intelligence Scales for Children 4th Edition
business
Zdroj: Acta Paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
0803-5253
Popis: Aim The aim of the study was to investigate cognitive outcomes at 6.5 years in children born very preterm, in relation to neonatal characteristics and 2.5‐year neurodevelopment. Methods A prospective cohort, with gestational age 22.3‐31.9 weeks, born 2004‐2007, were examined at 2.5 years with the Bayley Scales of Infant and Toddler Development (Bayley‐III) (n = 100) and at 6.5 years with the Wechsler Intelligence Scales (n = 91). Results Neonatal factors independently related to 6.5‐year outcome were gestational age, retinopathy of prematurity and treated persistent ductus arteriosus. The Bayley‐III cognitive scores explained only 44% of the Full‐Scale Intelligence Quotient result at 6.5 years, and 22% of the children had Wechsler index results below −1 SD, indicating cognitive impairment, after average test results at 2.5 years. The relative risk to score below −1 SD on the Full‐Scale IQ was 2.83 (95% CI 1.45‐5.53) in children with gestational age below 28 weeks and 2.22 (95% CI 1.18‐4.17) at gestational age 28‐31 weeks. Conclusion Very preterm infants born in the 2000s had increased risks for impaired cognition at 6.5 years, but individual predictions based on neonatal risks and 2.5‐year test results were not enough to identify all high‐risk children.
Databáze: OpenAIRE
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