Increased rate of lumbar spondylolisthesis in rheumatoid arthritis: A case-control study
| Autor: | Marine Forien, Florence Tubach, Sébastien Ottaviani, Toni Alfaiate, Benjamin Hagege, Philippe Dieudé |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Clinical Biochemistry Population Biochemistry Anti-Citrullinated Protein Antibodies Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Lumbar Interquartile range Rheumatoid Factor Internal medicine otorhinolaryngologic diseases medicine Odds Ratio Prevalence Rheumatoid factor Humans education Aged 030203 arthritis & rheumatology education.field_of_study Lumbar Vertebrae business.industry General Medicine Odds ratio Middle Aged medicine.disease Low back pain Spondylolisthesis Radiography Rheumatoid arthritis Case-Control Studies Multivariate Analysis Female sense organs France medicine.symptom business Low Back Pain 030217 neurology & neurosurgery |
| Zdroj: | European journal of clinical investigation. 48(9) |
| ISSN: | 1365-2362 |
| Popis: | OBJECTIVE The aim of this study was to compare the prevalence of lumbar spondylolisthesis (SPL) in patients suffering from low back pain (LBP) with or without rheumatoid arthritis (RA) and to identify potential factors associated with SPL in patients with RA. METHODS We performed a case-control study. Cases and control patients had chronic LBP (more than 4 weeks). Patient with RA fulfilled the 2010 ACR/EULAR criteria. The main outcome was the presence of lumbar SPL on lumbar X-ray. The prevalence of SPL between RA and control patients was compared using chi-squared test. Potential factors associated with SPL in patients with RA were investigated by univariate and multivariate analysis, estimating odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS A total of 67 cases and 83 controls were included. Median [interquartile range] age of patients with RA was 60.0 years [51.0-72.0]; 80.6% were females; and 92.5% and 83.6% were positive for anti-citrullinated protein antibodies (ACPAs) or rheumatoid factor, respectively. Mean RA disease duration was 11.2 ± 8.7 years. SPL was more frequent in patients with RA than controls (41.8% versus 18.1%, P = 0.001). Adjusted to gender, RA was associated with increased prevalence of SPL (OR 3.15 [95% CI 1.48-6.70], P = 0.003). Among patients with RA, SPL was mainly Grade 1 (85.7%). Multivariate analysis revealed SPL is associated with increased age in patients with RA (OR 1.06 [1.02-1.11], P = 0.004). CONCLUSION In a population of patients with chronic LBP, the prevalence of lumbar SPL was higher with than without RA. SPL might be explained by synovitis of lumbar facet joints. |
| Databáze: | OpenAIRE |
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