Viable tumor in salvage neck dissections in head and neck cancer: Relation with initial treatment, change of lymph node size and human papillomavirus
| Autor: | Johannes A. Langendijk, Bart Dorgelo, Ed Schuuring, Gyorgy B. Halmos, Hendrik P. Bijl, Karlijn van den Bovenkamp, Bert van der Vegt, Boudewijn E. C. Plaat, Bernard F. A. M. van der Laan, Sjoukje F. Oosting, Boukje A. C. van Dijk, Jan L. N. Roodenburg, Maartje G. Noordhuis |
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| Přispěvatelé: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Man, Biomaterials and Microbes (MBM), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Targeted Gynaecologic Oncology (TARGON) |
| Rok vydání: | 2018 |
| Předmět: |
Male
HPV Cancer Research medicine.medical_specialty medicine.medical_treatment Salvage therapy Neck dissection Alphapapillomavirus THERAPY CHEMORADIATION 03 medical and health sciences 0302 clinical medicine Recurrence Squamous cell carcinoma medicine Humans Head and neck cancer 030223 otorhinolaryngology Lymph node Aged Retrospective Studies Cetuximab Squamous Cell Carcinoma of Head and Neck business.industry Cancer Middle Aged medicine.disease Radiation therapy PET medicine.anatomical_structure Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Female Lymph Nodes SQUAMOUS-CELL CARCINOMA Radiology Oral Surgery business Watchful waiting medicine.drug |
| Zdroj: | Oral Oncology, 77, 131-136. ELSEVIER SCIENCE BV |
| ISSN: | 1368-8375 |
| Popis: | Objectives: To identify predictive factors for the presence of viable tumor and outcome in head and neck cancer patients who undergo therapeutic salvage neck dissections.Materials and Methods: Retrospective analysis of 76 salvage neck dissections after radiotherapy alone (n = 22), radiotherapy in combination with carboplatin/5-fluorouracil (n = 42) or with cetuximab (n = 12).Results: Viable tumor was detected in 41% of all neck dissections. Univariate analysis revealed initial treatment with radiotherapy without systemic therapy (OR 6.93, 95%CI: 2.28-21.07, p Conclusions: Viable tumor in salvage neck dissections is associated with reduced survival. Radiotherapy alone, human papillomavirus negative cancer and increase in lymph node size, are associated with viable tumor in salvage neck dissections. In case of decreased or stable lymph node size after chemoradiation, watchful waiting could be considered. |
| Databáze: | OpenAIRE |
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