HLA-G polymorphism in Finnish couples with recurrent spontaneous miscarriage
| Autor: | Tarja Laitinen, Anja Tiilikainen, Jari Karhukorpi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Genetics
Abortion Habitual Pregnancy Polymorphism Genetic Spontaneous miscarriage Histocompatibility Antigens Class I Haplotype Genes MHC Class I Obstetrics and Gynecology Locus (genetics) Human leukocyte antigen Biology medicine.disease Pathogenesis Gene Frequency HLA-G Immunology medicine Humans Female Allele Finland |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 104:1212-1214 |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | HLA-G is a class I major histocompatibility complex gene that is expressed in cytotrophoblasts at the materno-fetal interface. It has been suggested that HLA-G could play a key role in materno-fetal immunological interactions during pregnancy. To investigate whether there is an association between HLA-G locus and recurrent spontaneous miscarriage, HLA-G alleles were determined by a PCR-RFLP method in 38 couples with recurrent spontaneous miscarriage and in 26 random control couples. In this series parental HLA-G sharing, extended HLA-G/A haplotypes and the frequencies of the HLA-G alleles were similar in the two groups. Thus, our data suggest that there is no detectable relation between susceptibility to recurrent spontaneous miscarriage and HLA-G locus. |
| Databáze: | OpenAIRE |
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