Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors
| Autor: | Amy Liang, Dao Lentz, Lan Trinh, Yuo-Ling Chou, Brad O. Buckman, David R. Light, Raju Mohan, Kenneth J. Shaw, Morrissey Michael M, Meg Mccarrick |
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| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular Proteases Stereochemistry Clinical Biochemistry Amidines Molecular Conformation Pharmaceutical Science Factor VIIa Naphthols Biochemistry Reductive amination Thromboplastin Serine Acylation Amidine chemistry.chemical_compound Tissue factor Structure-Activity Relationship Drug Discovery Humans Molecular Biology Binding Sites Aryl Organic Chemistry Small molecule Kinetics chemistry Molecular Medicine |
| Zdroj: | Bioorganicmedicinal chemistry letters. 15(9) |
| ISSN: | 0960-894X |
| Popis: | Reductive amination followed by acylation of polymer-linked formyl aryl amidines generate combinatorial libraries of aryl amidines 8-13. Potent small molecule naphthylamidine inhibitors 12 (Ki |
| Databáze: | OpenAIRE |
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