Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients
| Autor: | Massimo Bonora, Massimiliano Castellazzi, Mariapina Donadio, Maura Pugliatti, Enrico Granieri, Paolo Pinton, Carlotta Giorgi, Simone Patergnani, Enrico Fainardi, Ilaria Casetta |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Immunology ATG5 Cellular homeostasis Autophagy Biomarkers Magnetic resonance imaging Mitophagy Multiple sclerosis Parkin lcsh:RC346-429 NO Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Internal medicine medicine Humans lcsh:Neurology. Diseases of the nervous system Retrospective Studies medicine.diagnostic_test business.industry General Neuroscience Research Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Endocrinology Neurology Female business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-8 (2019) |
| Popis: | Background An alteration of autophagy and mitophagy, two highly conserved lysosome-dependent degradation pathways involved in the maintenance of cellular homeostasis, has been associated with multiple sclerosis (MS). Objective To search the level of autophagy-related 5 (ATG5) and Parkin proteins, as markers of autophagy and mitophagy respectively, and lactate in a cohort of MS patients. Methods Cerebrospinal fluid (CSF) and serum samples from 60 MS patients were analyzed: 30 with magnetic resonance imaging (MRI) evidence of disease activity, gadolinium (Gd)-based contrast agent positive (Gd+), and 30 without MRI evidence of disease activity (Gd−). ATG5, Parkin, and lactate were measured using commercially available products. Results and conclusions Serum levels of ATG5, Parkin, and lactate were more elevated in Gd+ than in Gd− MS patients (p |
| Databáze: | OpenAIRE |
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