The frequency of QAP2.1 is increased in psoriasis vulgaris patients but no unusual linkage between QAP/DQA1 or QBP/DQB1
| Autor: | Irma Ikäheimo, Jaakko Karvonen, Sylvi Silvennoinen-Kassinen, Anja Tiilikainen |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Genetic Linkage Haplotype Cytogenetics HLA-DR Antigens Dermatology General Medicine Human leukocyte antigen Biology medicine.disease Phenotype ATP Binding Cassette Transporter Subfamily B Member 3 HLA-DQ Antigens Psoriasis Immunology medicine biology.protein Humans TAP2 ATP-Binding Cassette Transporters ATP Binding Cassette Transporter Subfamily B Member 2 Allele TAP1 |
| Zdroj: | Archives of Dermatological Research. 289:373-377 |
| ISSN: | 1432-069X 0340-3696 |
| Popis: | Psoriasis vulgaris is a chronic skin disease with a genetic and immunological background. We have previously defined the two most frequent risk haplotypes in Finns: A2,B13,Cw6,DR7,DQA1*0201 and A1,B17,Cw6,DR7,DQA1*0201. The aim of this study was to further examine whether the flanking regions, URRs of DQ (QAP and QBP) and TAP1 and TAP2 genes are involved in susceptibility to psoriasis. The frequency of QAP2.1 was increased in psoriatics as compared with controls ( P c = 3.6 × 10 –2 , RR = 5.0), and the frequency of QAP4.1 was decreased in psoriasis patients ( P c = 4.2 × 10 –2 ). The frequency of the phenotype combination Val/Ile at position 379 of TAP2 was decreased in patients ( P c = 1 × 10 –2 ). The allele and phenotype frequencies of TAP1 and TAP2 genes were not different between these groups. Haplotypes A2, B13,Cw6,DR7,DQA1*0201,QAP2.1 and A1,B17,Cw6, DR7,DQA1*0201,QAP2.1 are the two most frequent HLA marker haplotypes for psoriasis vulgaris in Finns, Cw6, DR7, DQA1*0201 and QAP2.1 being the most important single alleles for the risk of this disease. |
| Databáze: | OpenAIRE |
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