Effects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence, Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder
| Autor: | İbrahim Karakaya, Erol Göka, Hilmiye Nesrin Dilbaz, Mehmet Ali Kaşifoğlu, Yavuz Ayhan, Başaran Demir, Melih O. Babaoglu, Berna Uluğ, Şeref Can Gürel, Sevilay Karahan |
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| Přispěvatelé: | Kapadokya Üniversitesi, Beşeri Bilimler Fakültesi, Psikoloji Bölümü |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Nitric oxide synthase Impulsiveness Alcohol dependence Research Diagnostic Criteria General Medicine medicine.disease Impulsivity Comorbidity Attention deficit hyperactivity disorder Psychiatry and Mental health Barratt Impulsiveness Scale Polymorphism (computer science) Internal medicine mental disorders medicine Gene polymorphism medicine.symptom business |
| Zdroj: | Turkish Journal of Psychiatry. |
| ISSN: | 1300-2163 |
| DOI: | 10.5080/u22980 |
| Popis: | Gurel, Seref Can/0000-0003-3261-6611 WOS: 000496714500002 PubMed ID: 31487373 TARAMASCOPUS TARAMAPUBMED TARAMAWOS TARAMATRDİZİN Objective: We planned to compare individuals with alcohol dependence (AD) and healthy controls on the frequency of NOS1 exon 1f-VNTR gene polymorphism and to investigate the effects of this polymorphism on the clinical symptoms of alcohol dependence, impulsiveness and comorbid attention deficit hyperactivity disorder (ADHD) symptoms. Method: A total of 282 participants consisting of 153 patients and 129 age and gender matched healthy individuals were inluded in the study. All participants were evaluated with Structured Clinical Interview for DSM-IV Axis 1 disorders (SCID-I) and Michigan Alcohol Screening Test (MAST), Barratt Impulsiveness Scale (BIS-11), UPPS Impulsive Behavior Scale, Adult Attention Deficit and Hyperactivity Diagnosis Scale (ADHDS), Family History Research Diagnostic Criteria (FHDRC). The QF-PCR fragment protocols were used for genetic analyses. Allele fragments of 176 bp sizes were separated and 3 different genotypes were determined as the SS, SL and LL. Associations of these genotypes with symptoms of AD severity, impulsiveness and comorbid ADHD were investigated. Results: The AD and control groups did not differ significantly on the basis of NOS1 exon 1f-VNTR gene polymorphism. Also, significant correlations between this polymorphism and symptoms of AD severity, impulsiveness and ADHD were not determined. Conclusion: Results of our study do not indicatea significant association between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of AD, impulsiveness or comorbid ADHD semptoms. |
| Databáze: | OpenAIRE |
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