Isoindolinone-containing meroterpenoids with α-glucosidase inhibitory activity from mushroom Hericium caput-medusae
| Autor: | Lin Chen, Ji-Kai Liu, Tao Feng, Yue-Ling Peng, Zheng-Hui Li, Rong Huang, Jian-Neng Yao |
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| Rok vydání: | 2017 |
| Předmět: |
Indoles
Stereochemistry 010402 general chemistry 01 natural sciences chemistry.chemical_compound Drug Discovery Hericium Glycoside Hydrolase Inhibitors Fruiting Bodies Fungal Fermentation broth α glucosidase inhibitory Pharmacology Meroterpene Mushroom biology Molecular Structure 010405 organic chemistry Terpenes Chemical shift Basidiomycota alpha-Glucosidases General Medicine biology.organism_classification 0104 chemical sciences chemistry Proton NMR Agaricales Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Fitoterapia. 122 |
| ISSN: | 1873-6971 |
| Popis: | Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins C-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration. The absolute configurations of 10 and 11 were rationalized by the calculation of 1H NMR chemical shifts. Caputmedusins A-C (1-3) showed moderate inhibitory activity against α-glucosidase with the IC50 values of 39.2, 36.2 and 40.8μM, respectively. |
| Databáze: | OpenAIRE |
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