Persistence of sexual behavior in ovariectomized stumptail macaques following dexamethasone treatment or adrenalectomy
| Autor: | Michael J. Baum, D.L. Westbroek, A. Koos Slob, F. H. De Jong |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Receptivity Macaque Dexamethasone Sexual Behavior Animal Behavioral Neuroscience Endocrinology Dexamethasone Sodium Phosphate Internal medicine biology.animal medicine Animals Testosterone Castration Drug Implants Estradiol biology Endocrine and Autonomic Systems Adrenalectomy Testosterone (patch) Haplorhini Silastic Ovariectomized rat Macaca Female Psychology medicine.drug |
| Zdroj: | Hormones and Behavior. 11:323-347 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/0018-506x(78)90036-3 |
| Popis: | Daily administration over a period of 6 weeks of increasing doses of dexamethasone sodium phosphate (DEX) to seven long-term ovariectomized female stumptail monkeys significantly lowered circulating levels of testosterone without reducing any aspect of the females' sexual behavior or that of their male partners. Since treatment with DEX failed to suppress serum testosterone levels completely an additional experiment was performed in which the sexual behavior of five ovariectomized stumptails was compared before and after bilateral adrenalectomy, combined with chronic administration of both gluco- and mineralocorticoids. Serum levels of both testosterone and estradiol were reduced to very low levels in females after ovariectomy and adrenalectomy, yet no significant depression of females' sexual performance or that of their male partners occurred. Subsequent sc administration of estradiol or estradiol + testosterone in Silastic capsules to ovariectomized, adrenalectomized stumptails had little effect on sexual interaction. In a third experiment five ovariectomized stumptails which initially were relatively unreceptive and unattractive to males were given first testosterone and then testosterone + estradiol sc in Silastic capsules. One of the three indexes of females' receptivity increased significantly after testosterone; however, no other essential aspect of sexual interaction was affected. These findings suggest that sex steroids are normally not required in the female stumptail macaque for activation of preceptive and receptive sexual behaviors or for maintenance of sexual attractivity. |
| Databáze: | OpenAIRE |
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