Application of molecularly imprinted polymer based matrix solid phase dispersion for determination of fluoroquinolones, tetracyclines and sulfonamides in meat
Autor: | Ju Xiang Liu, Geng Nan Wang, Lei Zhang, Jian Ping Wang, Yi Ping Song |
---|---|
Rok vydání: | 2017 |
Předmět: |
Swine
Clinical Biochemistry 01 natural sciences Biochemistry Analytical Chemistry Molecular Imprinting Matrix (chemical analysis) Limit of Detection Animals Solid phase extraction Chromatography High Pressure Liquid Detection limit Sulfonamides Chromatography 010405 organic chemistry Chemistry Elution Solid Phase Extraction 010401 analytical chemistry Extraction (chemistry) Molecularly imprinted polymer Reproducibility of Results Cell Biology General Medicine 0104 chemical sciences Solvent Red Meat Tetracyclines Linear Models Molecular imprinting Fluoroquinolones |
Zdroj: | Journal of Chromatography B. :104-111 |
ISSN: | 1570-0232 |
Popis: | In this study, a type of novel mixed-template molecularly imprinted polymer was synthesized that was able to recognize 8 fluoroquinolones, 8 sulfonamides and 4 tetracyclines simultaneously with recoveries higher than 92%. Then the polymer was used to develop a matrix solid phase dispersion method for simultaneous extraction of the 20 drugs in pork followed by determination with ultra performance liquid chromatography. During the experiments, the MMIP amount, washing solvent and elution solvent were optimized respectively. The limits of detection of this method for the 20 drugs in pork were in the range of 0.5-3.0ngg-1, and the intra-day and inter-day recoveries from the fortified blank samples were in the range of 74.5%-102.7%. Therefore, this method could be used as a rapid, simple, specific and sensitive method for multi-determination of the residues of the three classes of drugs in meat. |
Databáze: | OpenAIRE |
Externí odkaz: |