Simvastatin improves morphological and functional recovery of sciatic nerve injury in Wistar rats
| Autor: | A.M. Xavier, Emerson José Venâncio, Niara Vanat, Claudia Patrícia Cardoso Martins Siqueira, Dayla Thyeme Higashi, K.K.M. da C. Flaiban, Karla G. G. Serafim, S. de Paula Ramos |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Simvastatin medicine.medical_specialty Wallerian degeneration Spleen Motor Activity Lesion Peripheral Nerve Injuries Internal medicine medicine Animals Rats Wistar General Environmental Science business.industry Recovery of Function Sciatic nerve injury medicine.disease Sciatic Nerve Nerve Regeneration Rats Surgery Mononuclear cell infiltration Endocrinology medicine.anatomical_structure Peripheral nervous system General Earth and Planetary Sciences Sciatic nerve medicine.symptom business medicine.drug |
| Zdroj: | Injury. 43:284-289 |
| ISSN: | 0020-1383 |
| DOI: | 10.1016/j.injury.2011.05.036 |
| Popis: | The purpose of this work is to investigate the effects of simvastatin on sciatic nerve regeneration in male Wistar Rats.Forty animals were allocated into four groups: (1) control (C); (2) control+simvastatin (CS); (3) lesioned animals+sterile PBS (LC) and (4) lesioned animals+simvastatin (LS). Lesioned animals were submitted to crushing lesion of right sciatic nerve. Simvastatin (20mg/kg/day, i.p.) was administered for five days. Footprints were obtained weekly for evaluation of functional locomotor recovery by means of the Sciatic Function Index (SFI). Blood samples were obtained weekly for quantifying circulating leukocytes. Animals were sacrificed after 21 days for histological analyses of sciatic nerve and spleen.LS Animals presented increased SFI scores, decreased areas of oedema and mononuclear cell infiltration during Wallerian degeneration and nerve regeneration (7,14 and 21 days; P0.05). Spleen weight and white pulp areas was increased in LC animals after 21 days. Increased numbers of circulating neutrophils were observed in simvastatin treated animals (CS e LS) at seven, 14 and 21 days, compared to non-treated groups (C and LC).The study suggests that simvastatin accelerates the morphological and functional recovery process of the peripheral nervous system interfering with innate and acquired immunity. |
| Databáze: | OpenAIRE |
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