Studies on 44 081 R.P., a new antirhinovirus compound, in cell cultures and in volunteers
| Autor: | D. A. J. Tyrrell, P.G. Higgins, A. Zerial, J. S. Willmann, R. J. Phillpotts, G. H. Werner |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Time Factors Adolescent Rhinovirus Antimetabolites Common Cold Microbial Sensitivity Tests Biology medicine.disease_cause Antiviral Agents Virus Microbiology In vivo Tetrahydroisoquinolines medicine Humans Pharmacology (medical) Cells Cultured Pharmacology Biological activity Middle Aged Virology In vitro Thiazoles Infectious Diseases Viral replication Mechanism of action Female Nasal administration medicine.symptom Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 27:846-850 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.27.5.846 |
| Popis: | A synthetic compound, 2-[(1,5,10,10a-tetrahydro-3H-thiazolo[3,4b]isoquinolin-3-ylidene) amino]-4-thiazoleacetic acid (S), 44 081 R.P., inhibits the multiplication of rhinoviruses in cell cultures. Of the 69 rhinovirus strains and serotypes that have been studied, 39% were inhibited at a concentration of 7 micrograms/ml, far below that which affects cellular metabolism (250 micrograms/ml). Preliminary data indicate that the compound inhibits some early events of virus replication but that some cellular functions are also involved in its mechanism of action. Despite its antiviral activity in vitro, the compound, when self-administered intranasally as a 0.2% solution to volunteers from the day before to 5 days after inoculation with a human rhinovirus strain, had no significant effect on rhinorrhea, clinical score, or laboratory evidence of infection. |
| Databáze: | OpenAIRE |
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