The left border of the genomic inversion of pseudorabies virus contains genes homologous to the UL46 and UL47 genes of herpes simplex virus type 1, but no UL45 gene
| Autor: | Sybille Dezélée, Xuan Nguyen, Anne Flamand, Marie Jo Masse, Françoise Bras, Patrice Vende, Brigitte Simonet |
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| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
Genes Viral Transcription Genetic viruses Molecular Sequence Data Biology medicine.disease_cause Genome Virus Viral Proteins Intergenic region Virology Chlorocebus aethiops medicine Animals Humans Amino Acid Sequence Gene Vero Cells Chromosomal inversion Genetics Sequence Homology Amino Acid Herpesvirus 1 Suid Open reading frame Infectious Diseases Herpes simplex virus Chromosome Inversion BamHI Viral Fusion Proteins |
| Zdroj: | Virus research. 60(1) |
| ISSN: | 0168-1702 |
| Popis: | The genome of pseudorabies virus (PrV) is collinear with the herpes simplex virus type 1 (HSV1) genome, except for an inversion in the unique long region, the right extremity of which resides within the BamHI fragment 9 and the left within the BamHI fragment 1. We previously sequenced the right border of the inversion which is situated next to the UL44-gC gene and found that it encodes the UL24, UL25, UL26 and UL26.5 gene counterparts of HSV1. We have now sequenced 5317 base pairs of the BamHI fragment 1, upstream of the UL27-gB gene. We found two open reading frames homologous to UL46 and UL47 of HSV1 yet UL45 was absent and replaced by a set of strictly repeated sequences. PrV UL46 and UL47 are transcribed into two 3' co-terminal messenger RNAs with early and late kinetics, respectively. Comparison of the PrV UL46 and UL47 protein sequences with their counterparts from alphaherpesviruses indicated a strong similarity. The genome is rearranged in this region with respect to HSV1 and the inversion must have taken place, on the left side, within the UL46-UL27 intergenic region. Thus, the inversion should include genes UL27 to UL44. |
| Databáze: | OpenAIRE |
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