Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC-ESI-MS/MS
| Autor: | Giselle Tamayo-Castillo, Elisabet Fuguet, Libia Herrero-Uribe, Allan Jiménez-Ardón, María Luisa Mateos-Martín, Josep Lluís Torres |
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| Rok vydání: | 2014 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Stereochemistry Electrospray ionization Chemistry Pharmaceutical medicine.disease_cause Tandem mass spectrometry Biochemistry Antiviral Agents Analytical Chemistry chemistry.chemical_compound Structure-Activity Relationship Phenols Tandem Mass Spectrometry medicine Structure–activity relationship Humans Proanthocyanidins Chamaecrista Chamaecrista nictitans Flavonoids Chromatography biology Chemistry Plant Extracts Polyphenols Herpes Simplex Free Radical Scavengers biology.organism_classification Flavones Afzelechin Herpes simplex virus Proanthocyanidin Polyphenol DNA Viral Chromatography Liquid |
| Zdroj: | Analytical and bioanalytical chemistry. 406(22) |
| ISSN: | 1618-2650 |
| Popis: | Chamaecrista nictitans (L) extract possesses antivi- ral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high- resolution LC-ESI-MS/MS is used to identify the phenolic components of the most potent fraction of the extract. The fraction is a complex mixture rich in oligomeric proanthocyanidins with a high content of monohydroxyphenol moieties ((epi)fisetinidol, (epi)afzelechin and (epi)guibourtinidol) and A-type linkages, uncommon in other proanthocyanidin-rich phenolic extracts, such as those from grape seeds or pine bark. As monohydroxyphenolic structures and A-type linkages have been related to antiviral effects, par- ticularly through the inhibition of late transcription, we suggest that the fraction of C. nictitans extract exerts its action through a particularly effective combination of proanthocyanidins that include these two structural features. |
| Databáze: | OpenAIRE |
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