Trace-Level Persistent Organic Pollutant Analysis with Gas-Chromatography Orbitrap Mass Spectrometry-Enhanced Performance by Complementary Acquisition and Processing of Time-Domain Data
| Autor: | Konstantin O. Nagornov, Anton N. Kozhinov, Davide Bleiner, Markus Zennegg, Yury O. Tsybin |
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| Rok vydání: | 2020 |
| Předmět: |
Chromatography
Resolution (mass spectrometry) Chemistry 010401 analytical chemistry Replicate 010402 general chemistry Orbitrap Mass spectrometry 01 natural sciences Fourier transform ion cyclotron resonance 0104 chemical sciences law.invention Data acquisition Structural Biology law Mass spectrum Time domain Spectroscopy |
| Zdroj: | Journal of the American Society for Mass Spectrometry. 31(2) |
| ISSN: | 1879-1123 |
| Popis: | The range of commercial techniques for high-resolution gas-chromatography-mass spectrometry (GC-MS) has been recently extended with the introduction of GC Orbitrap Fourier transform mass spectrometry (FTMS). We report on progress with quantitation performance in the analysis of persistent organic pollutants (POP), by averaging of time-domain signals (transients), from a number of GC-FTMS experiment replicates. Compared to a standard GC-FTMS measurement (a single GC-FTMS experiment replicate, mass spectra representation in reduced profile mode), for the 10 GC-FTMS technical replicates of ultratrace POP analysis, sensitivity improvement of up to 1 order of magnitude is demonstrated. The accumulation method was implemented with an external high-performance data acquisition system and dedicated data processing software to acquire the time-domain data for each GC-FTMS replicate and to average the acquired GC-FTMS data sets. Concomitantly, the increased flexibility in ion signal detection allowed the attainment of ultrahigh-mass resolution (UHR), approaching R = 700 000 at m/z = 200. |
| Databáze: | OpenAIRE |
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