Treatment with a Uroselective α1‐Blocker Improves Voiding and Sexual Function: A Study in Thai Men with Lower Urinary Tract Symptoms
| Autor: | Sompol Permpongkosol, Krisada Ratana-Olarn, Santichai Krilad‐O‐Larn |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Urologic Diseases medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism Prostatic Hyperplasia Urination Endocrinology Erectile Dysfunction Quality of life Lower urinary tract symptoms medicine Humans Alfuzosin Aged business.industry Penile Erection Middle Aged Thailand medicine.disease Psychiatry and Mental health Exact test Erectile dysfunction Sexual dysfunction Reproductive Medicine Adrenergic alpha-1 Receptor Antagonists Quinazolines International Prostate Symptom Score medicine.symptom Sexual function business medicine.drug |
| Zdroj: | The Journal of Sexual Medicine. 8:2582-2589 |
| ISSN: | 1743-6095 |
| Popis: | Introduction Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) negatively affect quality of life. The α 1 ‐blockers are effective for LUTS suggestive of benign prostatic hypertrophy. Aim To analyze the effect of a uroselective α 1 ‐blocker on both voiding and sexual dysfunction in Thai men with LUTS. Methods Of 488 men with LUTS who received 10 mg alfuzosin monotherapy once daily (OD) at a men's health clinic, 313 men (64%) completed 8 months of alfuzosin treatment and filled the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function (IIEF)‐5 questionnaires. Main Outcome Measure The relationships among the IPSS, IIEF‐5 score, and select clinical characteristics were analyzed using multiple regression analysis. To identify changes from the baseline, the chi‐square or Fisher's exact test was used for categorical or dichotomous variables and a paired Student's t ‐test was used for continuous variables. Results The 313 men were followed up for a mean (standard deviation [SD]) of 35.6 (2.2) weeks. LUTS were categorized by IPSS as moderate in 100 patients (31.9%) and severe in 213 patients (68.1%). ED was graded according to the IIEF‐5 as normal in 46 patients (14.7%), mild in 29 patients (9.3%), mild to moderate in 81 patients (25.9%), moderate in 47 patients (15.0%), and severe in 110 patients (35.1%). ED is associated with LUTS ( P = 0.008). After 8 months of alfuzosin treatment, the mean (SD) IPSS and IIEF‐5 score significantly improved from 19.95 (6.4) to 11.13 (4.6) ( P P Conclusion Treatment with 10 mg alfuzosin OD is safe and effective in improving voiding and sexual function in Thai men with LUTS and ED. Permpongkosol S, Krilad‐O‐Larn S, and Ratana‐O‐Larn K. Treatment with a uroselective α 1 ‐blocker improves voiding and sexual function: A study in Thai men with lower urinary tract symptoms. J Sex Med 2011;8:2582–2589. |
| Databáze: | OpenAIRE |
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