12-Month Coronary Angiography, Intravascular Ultrasound and Histology Evaluation of a Novel Fully Bioabsorbable Poly-L-Lactic Acid/Amorphous Calcium Phosphate Scaffolds in Porcine Coronary Arteries
| Autor: | Tim Wu, Zhiyuan Lan, Qiang Hu, Jun Li, Gaoke Feng, Roger J. Laham, Jianmin Xiao, Edward Kislauskis, Kan Wu, Xiaoxin Zheng, Zhao Lu, Xuejun Jiang, Stephen P. McCarthy, Yuying Bi |
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| Rok vydání: | 2016 |
| Předmět: |
Calcium Phosphates
medicine.medical_specialty Materials science Swine medicine.medical_treatment 0206 medical engineering Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Lumen (anatomy) Bioengineering 02 engineering and technology Coronary Angiography Prosthesis Design Blood vessel prosthesis Absorbable Implants Intravascular ultrasound medicine Animals General Materials Science Lactic Acid Longitudinal Studies Amorphous calcium phosphate Ultrasonography Interventional Tissue Scaffolds biology medicine.diagnostic_test business.industry Stent Histology 021001 nanoscience & nanotechnology biology.organism_classification Coronary Vessels 020601 biomedical engineering Blood Vessel Prosthesis Surgery Equipment Failure Analysis Coronary arteries medicine.anatomical_structure Taxus Stents 0210 nano-technology Nuclear medicine business |
| Zdroj: | Journal of Biomedical Nanotechnology. 12:743-752 |
| ISSN: | 1550-7033 |
| DOI: | 10.1166/jbn.2016.2241 |
| Popis: | Our previous studies have confirmed the superior biocompatibility of the poly-L-lactic acid/amorphous calcium phosphate (PLLA/ACP) scaffolds (PowerScaffold) compared to PLLA scaffolds and their similar 6-month radial strength compared with TAXUS stents. In order to conduct further dynamic observations on the performance of the PowerScaffold after 12-month implantation compared with the TAXUS stents. Twenty PowerScaffold and 20 TAXUS were implanted in porcine coronary arteries. At 12-month follow-up, Quantitative Coronary Angiography showed that the stent reference vessel diameter (3.19 ± 0.25 mm vs. 2.75 ± 0.22 mm, p < 0.05), the mean lumen diameter (3.07 ± 0.22 mm vs. 2.70 ± 0.17 mm, p < 0.05) and the late lumen gain (0.45 ± 0.07 mm vs. 0.06 ± 0.06 mm, p < 0.01) were all significantly greater with the PowerScaffold than the TAXUS. As well, Intravascular Ultrasound showed the stent reference vessel area (7.74 ± 0.48 mm2 vs. 6.96 ± 0.51 mm2, p < 0.05), the mean stent area (7.49 ± 0.46 mm2 vs. 6.53 ± 0.47 mm2, p < 0.05) and the mean lumen area (7.22 ± 0.50 mm2 vs. 6.00 ± 0.48 mm2, p < 0.01) were all significantly greater with the PowerScaffold than the TAXUS. The luminal patency rate of the PowerScaffold significantly increased from 72.45 ± 6.84% at 1 month to 93.54 ± 8.15% at 12 months (p < 0.01) while the TAXUS stents were associated with a non-significant decreasing trend (89.44 ± 8.44% vs. 86.53 ± 8.22%). Pathology indicated the average thickness of the struts degraded by 14.25 ± 3.04 μm at 1 month, 23.39 ± 2.45 μm at 6 months and 35.54 ± 2.20 μm at 12 months. Immunohistochemical examination showed that the expression of inflammatory factors NF-κB gradually decreased from 1-month to 12-month (36.79 ± 4.78 vs. 5.79 ± 2.85, P < 0.01). As the late lumen gain of arteries implanted with the PowerScaffold increases over time with the growth of vessels, it effectively reverse the late vascular negative remodeling observed with the TAXUS stents, providing a better option for lumen restoration treatment in clinical practice. |
| Databáze: | OpenAIRE |
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