Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients
| Autor: | O. Rasmussen, L. Ørskov, J. S. Christiansen, Per Heden Andersen, Oluf Pedersen, Sten Lund, J F Bak, Ole Schmitz, Niels Møller |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Monosaccharide Transport Proteins Biopsy Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucose uptake Muscle Proteins Fatty Acids Nonesterified Biology Carbohydrate metabolism Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Humans Glycogen synthase Glucose Transporter Type 4 Muscles Insulin Glucose transporter General Medicine Middle Aged Glucose clamp technique Glucagon medicine.disease Glucose Glycogen Synthase Diabetes Mellitus Type 2 Hyperglycemia Glucose Clamp Technique biology.protein Female Glipizide medicine.drug |
| Zdroj: | Acta Diabetologica. 31:31-36 |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/bf00580757 |
| Popis: | To examine whether sulphonylureas influence hyperglycaemia-induced glucose disposal and suppression of hepatic glucose production (HGP) in type 2 diabetes mellitus, a 150-min hyperglycaemic (plasma glucose 14 mmol/l) clamp with concomitant somatostatin infusion was used in eight type 2 diabetic patients before and after 6 weeks of glipizide (GZ) therapy. During the clamp a small replacement dose of insulin was given (0.15 mU/kg per min). Isotopically determined glucose-induced glucose uptake was similar before and after GZ administration which led to improved glycaemic control (basal plasma glucose 12.2 +/- 1.3 vs 8.9 +/- 0.7 mmol/l; P < 0.01). Glucose-induced suppression of HGP was, however, more pronounced during GZ treatment (0.96 +/- 0.14 vs 1.44 +/- 0.20 mg/kg per min; P < 0.02). Following GZ treatment hyperglycaemia failed to stimulate glycogen synthase activity. Moreover, GZ resulted in a significant increase in the immunoreactive abundance of the insulin-regulatable glucose transport protein (GLUT 4) (P < 0.02). In conclusion, these results suggest that GZ therapy in type 2 diabetic patients enhances hepatic sensitivity to hyperglycaemia, while glucose-induced glucose uptake remains unaffected. In addition, GZ tends to normalize the activity of glycogen synthase and increases the content of GLUT 4 protein in skeletal muscle. |
| Databáze: | OpenAIRE |
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