Studies of the c-Harvey-Ras gene in psychiatric disorders
| Autor: | D. Muhleman, S. Wu, Jeffrey Sverd, Connie Chiu, David E. Comings |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Genetic Markers Male Proband Obsessive-Compulsive Disorder medicine.medical_specialty Psychosis Adolescent Tourette syndrome Phobic disorder Proto-Oncogene Proteins p21(ras) Risk Factors medicine Humans HRAS Autistic Disorder Allele Child Psychiatry Alleles Biological Psychiatry Psychiatric Status Rating Scales Genetic Carrier Screening Mental Disorders Homozygote medicine.disease Developmental disorder Psychiatry and Mental health Genes ras Phobic Disorders Attention Deficit Disorder with Hyperactivity Child Preschool Schizophrenia Autism Female Psychology Tourette Syndrome |
| Zdroj: | Psychiatry Research. 63:25-32 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(96)02829-6 |
| Popis: | Herault et al. (1993) previously reported a significant association between autism and the larger fragments of the c-Harvey-Ras (HRAS) Bam H1 polymorphism. We have sought to verify this finding and determine if there was any evidence for an association with other psychiatric disorders. Because of its greater sensitivity, we have examined the HRAS Msp 1 polymorphism. We found a just significant increase in the prevalence of the > 2.1 kb alleles in 48 subjects with autism versus 50 control subjects. There was no increase in the prevalence of the > 2.1 kb alleles in 164 probands with Tourette's syndrome. Examination of 16 preselected symptom clusters, however, showed a significant trend toward higher scores for obsessive-compulsive and phobic symptoms in > 2.1 kb homozygotes. While this locus requires further study, in conjunction with the results of Herault et al., the present findings suggest that genetic defects in HRAS, and possibly other components of the G protein secondary messenger system, may play a role in some psychiatric disorders. |
| Databáze: | OpenAIRE |
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