Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: A single institutional experience and literature review
| Autor: | J. Raychaudhuri, Ling Zhang, Lia Perez, Ernesto Ayala, Rachid Baz, Salvador Bruno, Jennifer L. Cultrera, Eduardo M. Sotomayor, Lubomir Sokol, Jane Jijun Liu, Teresa Field, Paul A. Chervenick, Jose L. Ochoa-Bayona, Celeste M. Bello, Mohamed A. Kharfan-Dabaja |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Lymphoma B-Cell HIV Infections chemical and pharmacologic phenomena CHOP Immunophenotyping Internal medicine medicine Humans Aged Retrospective Studies business.industry Remission Induction Cancer Induction chemotherapy Hematopoietic stem cell Retrospective cohort study Hematology Middle Aged medicine.disease Combined Modality Therapy Lymphoma Treatment Outcome medicine.anatomical_structure Immunology Female business Plasmablastic lymphoma Follow-Up Studies |
| Zdroj: | Leukemia Research. 35:1571-1577 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2011.06.023 |
| Popis: | Plasmablastic lymphoma (PBL) is a rare aggressive B-cell lymphoproliferative disorder. HIV-negative PBL has not been extensively reported. Nine HIV-negative PBL patients evaluated at Moffitt Cancer Center were studied. Eight patients had extranodal diseases. All patients were treated with CHOP or hyper-CVAD. Responses were observed in 8 cases (7 complete, 1 partial responses). Four patients underwent consolidation with autologous hematopoietic stem cell transplant (HSCT) in first complete remission (CR1). At median follow-up of 23.9 months, 7 patients were alive and 5 were disease-free. Aggressive induction chemotherapy and consolidation with autologous HSCT in CR1 might be considered for patients with HIV-negative PBL. |
| Databáze: | OpenAIRE |
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