Two-Dimensional Barriers for Probing Conformational Shifts in Macrocycles

Autor:	Sungjoon Huh, Andrei K. Yudin, Solomon D. Appavoo, Shinya Kobori
Rok vydání:	2021
Předmět:	Colloid and Surface Chemistry Chemistry Nanotechnology General Chemistry 010402 general chemistry Mode of action 01 natural sciences Biochemistry Catalysis 0104 chemical sciences
Zdroj:	Journal of the American Chemical Society. 143:5166-5171
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.1c01248
Popis:	We describe the development and use of composite two-dimensional barriers in macrocyclic backbones. These tunable constructs derive their mode of action from heterocyclic rearrangements. The Boulton-Katritzky reaction has been identified as a particularly versatile means to effect a composite barrier, allowing the examination of the influence of heterocycle translocation on conformation. Kinetic studies using
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c1b039db84e3e9bf518a8f0acd7a35 https://doi.org/10.1021/jacs.1c01248 Zobrazit plný text záznamu