Goldfish CB1 mRNA expression is affected by fasting and anandamide administration
| Autor: | Ezio Campantico, Erika Cottone, Vincenzo Di Marzo, Alda Guastalla, Valentina Pomatto, Maria Fosca Franzoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cannabinoid receptor Polyunsaturated Alkamides medicine.medical_treatment Central nervous system Gene Expression Arachidonic Acids Biology Polymerase Chain Reaction chemistry.chemical_compound Prosencephalon Piperidines Receptor Cannabinoid CB1 Goldfish Internal medicine Cannabinoid Receptor Modulators Gene expression medicine Animals RNA Messenger Receptor Analysis of Variance musculoskeletal neural and ocular physiology General Neuroscience Fasting Anandamide Endocannabinoid system Actins Rhombencephalon Endocrinology medicine.anatomical_structure nervous system chemistry Forebrain Pyrazoles Female lipids (amino acids peptides and proteins) Cannabinoid psychological phenomena and processes Endocannabinoids |
| Popis: | The endocannabinoid system has a well-documented pivotal role in the control of mammalian feeding response; nevertheless, some evidence is available regarding a similar role in nonmammalian vertebrates and invertebrates. As in the bonyfish Carassius auratus, CB1 cannabinoid receptors are abundant in brain regions involved in the control of food intake, and fasting affects endocannabinoid levels, in this study the effects of food deprivation and anandamide administration on CB1 expression were evaluated. Fasting led to a time-dependent increase of CB1 mRNA levels in the forebrain, an effect reversed by refeeding. Furthermore, the administration of exogenous anandamide reduced CB1 expression in food-deprived goldfish. Our results support the involvement of CB1 receptors in the control of energy intake in nonmammalian vertebrates. |
| Databáze: | OpenAIRE |
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