LOW ERYTHROCYTE PYRIDOXAL- KINASE ACTIVITY IN BLACKS: ITS POSSIBLE RELATION TO FALCIPARUM MALARIA
| Autor: | G.J.F Esan, C.U. Hicks, V.C Okoye, LouisH. Miller, M.J Haut, John A. Kark, S.K Martin |
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| Rok vydání: | 1978 |
| Předmět: |
Adult
Erythrocytes Pyridoxal Plasmodium falciparum Black People Nigeria Dehydrogenase Glucosephosphate Dehydrogenase chemistry.chemical_compound parasitic diseases medicine Humans Glucose-6-phosphate dehydrogenase In patient Child Pyridoxal kinase activity biology Phosphotransferases Glucosephosphates General Medicine medicine.disease biology.organism_classification Malaria chemistry Immunology |
| Zdroj: | The Lancet. 311:466-468 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(78)90133-2 |
| Popis: | The red-cell glucose-6-phosphate dehydrogenase (G.-6-P.D.) activity and red-cell pyridoxal-kinase (P.L.K.) activity of 27 Nigerian children with severe Plasmodium falciparum parasitaemia were compared with those of 26 healthy Nigerian children and 6 White adults. The mean P.L.K. activity of the malaria patients was similar to that of the Whites but significantly higher than that of the Nigerian controls. Correction for reduced mean red-cell age in patients was made by comparing the P.L.K.: G.-6-P.D. ratio for those subjects with stable G.-6-P.D. phenotypes. The mean P.L.K.: G.-6-P.D. ratio was the same for malaria patients and adult Whites but significantly higher than that for the Nigerian controls. These results suggest that the relatively high frequency of low red-cell P.L.K. activity among Blacks may have been selected for by falciparum malaria. |
| Databáze: | OpenAIRE |
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