Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
| Autor: | Gregg P. Kotchey, Sanjay Mathur, Vincent Castranova, Alexey V. Tkach, Naveena Yanamala, Shyla Stanley, Ashley R. Murray, Valerian E. Kagan, Elena R. Kisin, Bengt Fadeel, Samantha Pareso, Alexander Star, Galina V. Shurin, Anna A. Shvedova, Michael R. Shurin, Timur O. Khaliullin |
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| Rok vydání: | 2012 |
| Předmět: |
Tris
Proteasome Endopeptidase Complex Fullerene Materials science Antigen presentation Oxide Article law.invention Biomaterials chemistry.chemical_compound Mice Antigen law MHC class I Animals General Materials Science Antigen Presentation biology Graphene Oxides General Chemistry Dendritic Cells Cell biology chemistry Immunology biology.protein Graphite Fullerenes Intracellular Biotechnology |
| Zdroj: | Small (Weinheim an der Bergstrasse, Germany). 9(9-10) |
| ISSN: | 1613-6829 |
| Popis: | Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines. |
| Databáze: | OpenAIRE |
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