Effect of ovariectomy and estrogen replacement on hypothalamic, pituitary and peripheral blood β-endorphin levels in the rat
| Autor: | S. Le, C.J. Chuong, T.A. Parkening |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
endocrine system
medicine.medical_specialty Pituitary gland medicine.drug_class Ovariectomy Hypothalamus Biology Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Estrus Anterior pituitary Pituitary Gland Anterior Internal medicine Blood plasma medicine Animals Estradiol Endocrine and Autonomic Systems beta-Endorphin Rats Inbred Strains Radioimmunoassay General Medicine Rats medicine.anatomical_structure Neurology chemistry Estrogen Estradiol benzoate Ovariectomized rat Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuropeptides. 20:175-180 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/0143-4179(91)90128-6 |
| Popis: | This study was initiated to detect possible changes in beta-endorphin (beta-EP) levels of the hypothalamus, anterior pituitary gland, and peripheral blood of rats after ovariectomy and estrogen administration. Attempts were also made to determine the correlation between peripheral and central levels of beta-EP. Twenty-six Sprague-Dawley rats were decapitated. Nine had intact ovaries (Gr. INT), and 17 were ovariectomized 3 weeks before they were killed. Nine of the ovariectomized rats received estradiol benzoate (EB) (Gr. EB) and the other 8 received peanut oil (Gr. OVX) prior to the decapitation. A beta-EP radioimmunoassay was used to analyze homogenates of the hypothalamus and anterior pituitary, and peripheral blood. In the hypothalamus, beta-EP levels were significantly lower in Gr. INT and Gr. EB than in Gr. OVX. In the pituitary gland and peripheral blood, beta-EP levels were significantly higher in Gr. INT than in Gr. OVX. Pituitary beta-EP levels did not vary between Gr. OVX and Gr. EB, although beta-EP levels in peripheral blood were significantly higher in Gr. EB than in Gr. OVX. No significant correlations were noted in beta-EP levels between the hypothalamus, pituitary gland, and peripheral blood in either Gr. INT, Gr. OVX, or Gr. EB. It appears that EB exerts different effects on beta-EP levels in the hypothalamus, anterior pituitary gland, and peripheral blood, and that beta-EP levels in these regions may be independent of one another. |
| Databáze: | OpenAIRE |
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