Association of the metabolic syndrome and long-term renal function in kidney donors
| Autor: | M. Vilatobá, R. Correa-Rotter, Roopa Mehta, Juan Mata, Paloma Almeda-Valdes, Carlos A. Aguilar-Salinas, Luis E. Morales-Buenrostro, F. Gabilondo-Navarro, Daniel Cuevas-Ramos, B. Gabilondo, M. Arvizu, Francisco J. Gómez-Pérez, Josefina Alberú |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Renal function Kidney Gastroenterology Internal medicine Medicine Humans Risk factor Proportional Hazards Models Metabolic Syndrome Transplantation business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Nephrectomy Tissue Donors Endocrinology medicine.anatomical_structure Surgery Female Metabolic syndrome business Body mass index Glomerular Filtration Rate |
| Zdroj: | Transplantation proceedings. 43(5) |
| ISSN: | 1873-2623 |
| Popis: | Metabolic syndrome (MetS) may represent risk factor for long-term renal function of kidneys from living donors. The aim of this study was to evaluate the impact of MetS on renal function in donors.Data regarding the presence or absence of MetS and renal function, as assessed by estimated glomerular filtration rate (eGFR) were obtained from 140 kidney donors before nephrectomy (BN) and at follow-up (AF). Donors were divided into those with (group 1; n =28) versus without MetS (group 2; n = 112).Comparing the groups, we observed a significantly greater reduction in eGFR among the group with MetS BN versus AF 27.5% (19.3-33.0) versus 21.4% (9.6-34.1 P = .02) respectively using a Cox regression model, including age, gender, serum uric acid, body mass index (BMI), and basal eGFR, MetS BN (hazard ratio = 2.2; 95% confidence interval [CI], 1.21-4.01; p = .01) was an independent factor associated with a greater risk of a-eGFR70 mL/min/1.73 m(2) at follow-up (P.001). Additionally, age (hazard ratio = 1.03%; 95% CI, 1.01-1.06; P.001), and female gender (hazard ratio = 1.86; 95% CI, 1.03-3.36; P = .03) were associated with a greater decrease in eGFR. Individuals with MetS BN showed a GFR70 mL/min/1.73 m(2) at significantly shorter follow-up time (5.6 ± 0.8 years) versus persons without MetS (12.8 ± 1.0 years; P = .001)Kidney donors with MetS BN experiment a significantly greater decrease in eGFR at follow-up. |
| Databáze: | OpenAIRE |
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