Using high-amplitude and focused transcranial alternating current stimulation to entrain physiological tremor
| Autor: | Jean-Marie Aerts, Ahmad Khatoun, Tom Haeck, Sara Op de Beeck, Laura Seynaeve, Myles Mc Laughlin, Boateng Asamoah, Ioana Gabriela Nica, Jolien Breukers |
|---|---|
| Přispěvatelé: | Sociology, Clinical sciences, Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science medicine.medical_treatment lcsh:Medicine stimulation Article 03 medical and health sciences 0302 clinical medicine medicine Using high-amplitude Prefrontal cortex lcsh:Science Tremor amplitude Transcranial alternating current stimulation Medicine(all) Multidisciplinary Transcranial direct-current stimulation High amplitude transcranial alternating lcsh:R entrain physiological tremor focused Physiological tremor stomatognathic diseases 030104 developmental biology Phosphene lcsh:Q Entrainment (chronobiology) 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that can entrain physiological tremor in healthy volunteers. We conducted two experiments to investigate the effectiveness of high-amplitude and focused tACS montages at entraining physiological tremor. Experiment 1 used saline-soaked sponge electrodes with an extra-cephalic return electrode and compared the effects of a motor (MC) and prefrontal cortex (PFC) electrode location. Average peak-amplitude was 1.925 mA. Experiment 2 used gel-filled cup-electrodes in a 4 × 1 focused montage and compared the effects of MC and occipital cortex (OC) tACS. Average peak-amplitude was 4.45 mA. Experiment 1 showed that unfocused MC and PFC tACS both produced phosphenes and significant phase entrainment. Experiment 2 showed that focused MC and OC tACS produced no phosphenes but only focused MC tACS caused significant phase entrainment. At the group level, tACS did not have a significant effect on tremor amplitude. However, with focused tACS there was a significant correlation between phase entrainment and tremor amplitude modulation: subjects with higher phase entrainment showed more tremor amplitude modulation. We conclude that: (1) focused montages allow for high-amplitude tACS without phosphenes and (2) high amplitude focused tACS can entrain physiological tremor. ispartof: Scientific Reports vol:8 issue:1 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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