Initial experience using Sivelestat to manage preterm labor with a bulging fetal membrane in pregnant women
| Autor: | N Masaoka, Y Nakajima |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Fetal Membranes Premature Rupture medicine.medical_specialty Serine Proteinase Inhibitors Preterm labor Obstetric Labor Glycine Magnesium Sulfate Young Adult chemistry.chemical_compound Obstetric Labor Premature Pharmacotherapy Pregnancy Fetal membrane medicine Humans Young adult reproductive and urinary physiology Sulfonamides Interleukin-6 Obstetrics business.industry Interleukin-8 Sivelestat Obstetrics and Gynecology Amniotic Fluid medicine.disease Tocolytic Agents chemistry Anesthesia Injections Intravenous Pediatrics Perinatology and Child Health Female Ritodrine business |
| Zdroj: | Journal of Perinatology. 32:466-468 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/jp.2011.132 |
| Popis: | Intrauterine infection and inflammation are recognized as major contributors to the onset of preterm labor. We describe two cases of severe preterm labor with bulging membrane that were treated by intravenous injection of Sivelestat, a neutrophil elastase inhibitor. Ritodrine hydrochloride and magnesium sulfate were intravenously administered for tocolysis, and ampicillin was provided as an antibiotic. Urinary trypsin inhibitor (UTI) was administered transvaginally. Sivelestat was infused intravenously at 4.8 mg kg(-1) day(-1) through the maternal vein. No side effects were observed. Levels of interleukin (IL)-6 and IL-8 in amniotic fluid decreased, and gestations were prolonged without complications for1 week. Two healthy infants were delivered. Our experience suggests that multidrug therapy with Sivelestat offers a new therapeutic strategy for preterm labor, but further investigations of the indications, administration period and dosage are required. |
| Databáze: | OpenAIRE |
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