Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
| Autor: | Raghuvir K. Arni, Mário T. Murakami, Magno M. Vicoti, José Ramon Beltran Abrego, Marco R. Lourenzoni, Marcelo A. Tomaz, Emerson Z. Arruda, Paulo A. Melo |
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| Přispěvatelé: | LNLS, Universidade Estadual Paulista (UNESP), Associated Researcher, Universidade Federal do Rio de Janeiro (UFRJ), Butantan Institute |
| Rok vydání: | 2008 |
| Předmět: |
Models
Molecular Platelet aggregation Protein Conformation Suramin Venom Reptilian Proteins Pharmacology Jararacussu Bothropstoxin II Biochemistry Group II Phospholipases A2 Mice Phospholipase A2 Structural Biology Catalytic Domain Crotalid Venoms Scattering Small Angle medicine Animals Bothrops Computer Simulation Creatine Kinase chemistry.chemical_classification Binding Sites biology General Medicine biology.organism_classification Phospholipases A2 Pharmacological activities Structural studies Enzyme chemistry biology.protein Electrophoresis Polyacrylamide Gel Algorithms medicine.drug |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0929-8665 |
| Popis: | Made available in DSpace on 2022-04-28T20:44:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-09-01 Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding. © 2008 Bentham Science Publishers Ltd. Center for Structural Molecular Biology Brazilian Synchrotron Light Laboratory LNLS, Campinas, SP Center for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SP Associated Researcher, São Carlos, SP Department of Basic and Clinical Pharmacology ICB UFRJ, RJ Center for Applied Toxinology Butantan Institute, São Paulo, SP Department of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000 Center for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SP Department of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000 |
| Databáze: | OpenAIRE |
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