Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
| Autor: | Narcis B. Kabatereine, James Cotton, Fiona Allan, Matthew Berriman, Alan Tracey, Nancy Holroyd, Joanne P. Webster, Jennifer D. Noonan, Poppy H. L. Lamberton, Duncan Berger, Moses Adriko, Thomas Crellen, Edridah M. Tukahebwa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Science 030231 tropical medicine Population General Physics and Astronomy Schistosomiasis Praziquantel Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Animals Humans Uganda Genetic variation Child education skin and connective tissue diseases 030304 developmental biology Schistosoma Ecological epidemiology Genetics 0303 health sciences education.field_of_study Multidisciplinary Whole Genome Sequencing biology Parasite genomics Schistosoma mansoni General Chemistry biology.organism_classification medicine.disease Schistosomiasis mansoni 3. Good health Parasitology Parasitic disease Human parasite Mass Drug Administration Female medicine.drug |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Control and elimination of the parasitic disease schistosomiasis relies on mass administration of praziquantel. Whilst these programmes reduce infection prevalence and intensity, their impact on parasite transmission and evolution is poorly understood. Here we examine the genomic impact of repeated mass drug administration on Schistosoma mansoni populations with documented reduced praziquantel efficacy. We sequenced whole-genomes of 198 S. mansoni larvae from 34 Ugandan children from regions with contrasting praziquantel exposure. Parasites infecting children from Lake Victoria, a transmission hotspot, form a diverse panmictic population. A single round of treatment did not reduce this diversity with no apparent population contraction caused by long-term praziquantel use. We find evidence of positive selection acting on members of gene families previously implicated in praziquantel action, but detect no high frequency functionally impactful variants. As efforts to eliminate schistosomiasis intensify, our study provides a foundation for genomic surveillance of this major human parasite. Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensive gene flow with limited positive selection suggesting minimal change post MDA. |
| Databáze: | OpenAIRE |
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