In vitro and in vivo anti-aging effects of compounds isolated from Artemisia iwayomogi
| Autor: | Wan Kyunn Whang, Cho Hi Park, Kyung Young Kim, Eun Ju Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Analytical chemistry
Ethyl acetate General Physics and Astronomy Fractionation 01 natural sciences General Biochemistry Genetics and Molecular Biology lcsh:Chemistry chemistry.chemical_compound Cosmeceuticals In vivo Scopoletin Anti-wrinkle effect General Materials Science Scopolin General Environmental Science lcsh:QD71-142 Traditional medicine 010405 organic chemistry Chemistry Artemisia iwayomogi 010401 analytical chemistry Skin whitening General Chemistry 0104 chemical sciences lcsh:QD1-999 Luteolin Cosmeceutical |
| Zdroj: | Journal of Analytical Science and Technology, Vol 10, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2093-3371 |
| DOI: | 10.1186/s40543-019-0193-1 |
| Popis: | In Korean folk medicine, Artemisia iwayomogi has largely been employed for the improvement of diabetic complications and hepatic function as well as in the treatment of female diseases and skin whitening. Accordingly, the present study sought to assess cosmeceutical activity of Artemisia iwayomogi. Through activity-guided fractionation, scopolin (AI-1), 2,4-dihydroxy-6-methoxy-acetophenone 4-O-β-D-glucoside (AI-2), scopoletin (AI-3), kaempferol-3-O-methyl ether (AI-4) and luteolin (AI-5) were isolated from ethyl acetate and water fractions of Artemisia iwayomogi. Of them, AI-4 and AI-5 exhibited strong antioxidative and whitening effects. In addition, AI-1, AI-3, AI-4, and AI-5 demonstrated considerable anti-wrinkle performances. According to results of quantitative analysis of compounds isolated from Artemisia iwayomogi, scopolin (AI-1) is a major component of Artemisia iwayomogi. Moreover, O/W type cream made by water fraction which included scopolin showed unwrinkling effect for 8 weeks when it was applied to face in an in vivo study. Specific contributions of Artemisia iwayomogi were as follows: AI-1, 1.21 mg/g; AI-2, 0.26 mg/g; AI-3, 0.38 mg/g; AI-4, 0.01 mg/g; and AI-5, 0.04 mg/g. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink