The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without delirium
| Autor: | Ryszard Jaszewski, Andrzej Banys, Tomasz Sobów, Jakub Kazmierski, Iwona Kłoszewska, Monika Sieruta, Pawel P. Liberski |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Rs6313 5-HT2A receptor Bioinformatics Receptors N-Methyl-D-Aspartate Postoperative Complications Gene Frequency mental disorders medicine Humans Receptor Serotonin 5-HT2A GRIN3A Coronary Artery Bypass Allele frequency Aged Polymorphism Genetic biology business.industry Haplotype Delirium Middle Aged GRIN2B Gene Psychiatry and Mental health Anesthesia Case-Control Studies biology.protein GRIN2B Female Poland medicine.symptom business |
| Zdroj: | General hospital psychiatry. 36(6) |
| ISSN: | 1873-7714 |
| Popis: | Objective The studies regarding the role of genes polymorphism in development of postoperative delirium are extremely rare. Therefore, we investigated the potential association of polymorphism in 5HT2a receptor gene and N -methyl-d-aspartate (NMDA) receptor 3A and 2B subunits genes with postoperative delirium. Method We conducted a prospective, nested, case–control study. For analysis, 3723G/A (rs3739722) polymorphism in the GRIN3A gene, 421C/A (rs3764028) polymorphism in the GRIN2B gene and T102C (rs6313) polymorphism in the 5HT2A gene were selected. Results Genetic analysis confirmed that there were significant differences in genotype frequencies for 3723G/A between delirium patients and controls. No other significant associations were observed. Moreover, according to the multivariate conditional logistic regression analysis the presence of AG haplotype of GRIN3A gene was independently associated with postoperative delirium. Conclusions These findings suggest that the genetic variations of NR3A subunit of NMDA receptor may be a predisposing factor to delirium among the Polish population of cardiac surgery patients. |
| Databáze: | OpenAIRE |
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